Design and synthesis of N-alkyl oxindolylidene acetic acids as a new class of potent Cdc25A inhibitors

Bioorg Med Chem Lett. 2008 Jun 1;18(11):3350-3. doi: 10.1016/j.bmcl.2008.04.027. Epub 2008 Apr 15.

Abstract

The oxindolylidene acetic acids having long N-alkyl chains exhibited strong inhibitory activity toward dual specificity phosphatase Cdc25A.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetates / chemical synthesis*
  • Acetates / chemistry
  • Acetates / pharmacology*
  • Drug Design*
  • Indoles / chemical synthesis*
  • Indoles / chemistry
  • Indoles / pharmacology*
  • Isatin / pharmacology
  • Molecular Structure
  • Structure-Activity Relationship
  • cdc25 Phosphatases / antagonists & inhibitors*

Substances

  • Acetates
  • Indoles
  • Isatin
  • cdc25 Phosphatases